Margaritas Mexican Cantina

4.7 ( 527 reviews )
Checking... 11:00 AM - 10:00 PM See Hours
$20–30
4725 Transit Rd, Depew, NY 14043, United States
+1 716-608-6385
Margaritas Mexican Cantina, located at 4725 Transit Rd, Depew, NY, has quickly become a local favorite, thanks to its vibrant atmosphere and exceptional service. Guests rave about the quality of food and handcrafted cocktails, especially the margaritas, which some call the best in town. The menu boasts a diverse selection of dishes, including standout tacos like the A La Diabla with grilled steak and chorizo, as well as vegetarian options that cater to all tastes. Reviewers commend the attentive service, noting friendly staff like Marx and Andrea, who enhance the dining experience with their warmth and recommendations. One vegetarian customer expressed delight at the thoughtful variety in plant-based offerings, such as the veggie enchiladas and chimichanga, which were loaded with fresh ingredients and bold flavors. The bustling atmosphere, adorned with colorful decorations, sets the perfect backdrop for savoring each dish. From complimentary chips and salsa to specialty items like birria burritos and chimichangas, every bite speaks to the care taken in preparation. Whether it's a casual dinner or a celebratory gathering, Margaritas Mexican Cantina delights with authentic flavors and a welcoming vibe, making it a must-visit destination for anyone craving Mexican cuisine.

Amenities and More

  • Accessibility
    • Has wheelchair-accessible car park
    • Has wheelchair-accessible entrance
    • Has wheelchair-accessible seating
    • Has wheelchair-accessible toilet
  • Service options
    • Has outdoor seating
    • Offers delivery
    • Offers takeaway
    • Serves dine-in
  • Highlights
    • Has fast service
    • Serves great cocktails
    • Has live music
    • Good for watching sport
  • Popular for
    • Popular for lunch
    • Popular for dinner
    • Good for solo dining
  • Offerings
    • Serves alcohol
    • Serves beer
    • Serves cocktails
    • Serves coffee
    • Serves comfort food
    • Serves happy-hour drinks
    • Serves happy-hour food
    • Quick bite
    • Serves small plates
    • Serves spirits
    • Serves vegetarian dishes
    • Serves wine
  • Dining options
    • Serves lunch
    • Serves dinner
    • Has catering
    • Serves dessert
    • Has seating
  • Amenities
    • Has bar on site
    • Has toilet
  • Atmosphere
    • Casual
    • Trendy
  • Crowd
    • Family friendly
    • Good for groups
  • Planning
    • Accepts reservations
  • Payments
    • Accepts credit cards
    • Accepts debit cards
    • Accepts NFC mobile payments
    • Credit cards
  • Children
    • Good for kids
    • High chairs available
    • Has kids' menu
  • Parking
    • Free of charge street parking
    • Free parking lot
    • Plenty of parking

Reviews For Margaritas Mexican Cantina

sue reese
Jun 3,2025
The food and atmosphere here are amazing! Their margaritas are the best around, and the food is top notch. Our server Marx was awesome and super friendly and helpful. Anytime we wanna have a Mexican and margs night this is our go to spot. The best
Amanda R
Apr 24,2025
Love the decorations and atmosphere. The food is delicious and there is a great selection on the menu. Our server, Andrea U was very attentive and kindly warned me about the green sauce being a little spicy for which I am grateful. I will definitely be back!
Parth Patel
Apr 19,2025
Absolutely loved my experience at this Mexican restaurant! As a vegetarian, I often find limited options at traditional spots, but this place really impressed me. The menu had a thoughtful variety of veg dishes—not just afterthoughts, but flavorful, well-crafted meals. The veggie enchiladas and chimichanga were packed with fresh ingredients and bold spices. The cheese sauce was a very unique and delicious surprise. Also, Jalapeno Margaritas exceded the expectations. It’s refreshing to see a Mexican restaurant put real effort into its vegetarian offerings. Highly recommend for anyone looking for authentic flavors done right. Will definitely be back!
Debra Wright
Apr 4,2025
Great Restaurant! 1st time we went and we will be back. They put chips and salsa down the minute you sit down. Ordered the chimichangas and Steak Fajita Quesdilla . Both were great !
Gerardo Guzman
Apr 2,2025
In March I celebrate my mother's birthday , and from the start everything and everyone was so friendly, that I felt like family. The attention and service is 200%, Stephanie was the server in charge and she is amazing. From the owner, GM Gerardo, Mimi, bartender Anna. Everything was way better than I expected. My #1 Mexican Restaurant in the whole area. Consistent food, attention. Amazing Job Margaritas My Respect. Sincerely: My Family and Me...
Ronald Campbell
Mar 23,2025
First time here and was Very Impressed with the Service, Atmosphere, Drinks and OMG the Food. Absolutely our New Favorite Mexican Restaurant. Andrea was our Outstanding Server and she is one of the many reasons we will be returning, often.
Hadlys Rafael Alvarez Wade
Feb 8,2025
Personally, I am a fan of Mexican food, and every time I travel, I make sure to visit a restaurant with that style of cuisine. This place is truly a gem—the food is delicious, the presentation and ambiance are unmatched, making it a whole experience. The service provided by Andrea U was wonderful; she took care of every detail to ensure we had everything we needed and felt super comfortable. The passion fruit margarita was my favorite, and the birria was the best I’ve ever had in my life. Don't hesitate to visit this place!
Bethany Brake
Feb 7,2025
Such a cool place! The decorations are gorgeous and colorful, it's nice and clean, and the food is very good. (I have to mention that the bathrooms are some of the nicest bathrooms I've ever seen, right down to the really pretty sinks. It's just a little detail, but it feels very luxe.) Staff was friendly and helpful and we enjoyed everything.

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